Novantrone (mitoxantrone)

By jefff Added at August 28, 2015 Views 1,289 Reviews 2

It is an antineoplastic (anti-cancer) medication given intravenously that is used as a disease-modifying treatment for people with MS. It is indicated for decreasing the frequency of relapses and progression of disability in people with secondary-progressive MS (SPMS), progressive-relapsing MS (PRMS), or worsening relapsing-remitting MS (RRMS).

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Reviews (2 reviews)

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jefff
jefff August 28, 2015 at 5:20 pm   

This is obviously a very SCARY drug and should ONLY be used in the ADVANCED stages of MS. Constant monitoring is needed due to the blood cell counts being affected as well as possible allergic reactions to the drug. Your liver function will be tested as well due to possible damage and the heart needs checking as well!

I realize there is a need for these types of advanced drugs in MS, but this a pretty scary medication, especially considering the warning given about a lifetime limit of 140mg.

Be CAREFUL and do your homework!!! jefff

jefff
jefff August 28, 2015 at 5:16 pm   
Pros

Its has the ability to cause the death of a range of human cells, including those that proliferate or reproduce at a rapid rate, such as cancerous tumors. Novantrone INHIBITS the PROLIFERATION of B-cells, T-cells, and macrophages that play an important role in the immune response which is thought to be involved in MS.

Cons

Novantrone is given by intravenous (IV) infusion through a needle that is placed in a vein in the arm. An infusion of Novantrone typically takes about 5 to 15 minutes. The recommended dosage of Novantrone is 12 mg/m2 (m2 refers to body mass or how heavy you are). There is a limit to how much Novantrone you can receive in your lifetime.

Due to the risk for damage to your heart, you should no. You should not take Novantrone if you are allergic to the medication or any of the ingredients contained in it (mitoxantrone hydrochloride, sodium chloride, sodium acetate, and acetic acid).t receive a cumulative lifetime dose greater than 140mg/m2.

Before prescribing Novantrone, your doctor will check you for a certain heart problem called reduced left ventricular ejection fraction (LVEF). If you have a 50% reduction in LVEF or a clinically significant reduction in LVEF, you should not take Novantrone.

Your doctor will also check your blood cell counts before you receive Novantrone. You should not receive Novantrone if your neutrophil (a type of white blood cell) count is less than 1500 cells/mm3.

Liver function should be monitored while you are receiving Novantrone. Novantrone clears more slowly from your body if liver function is impaired. Therefore, if your liver function is below normal, you should not take Novantrone.